Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory.

ABSTRACT: Recent work has established that visual working memory is subject to serial dependence: current information in memory blends with that from the recent past as a function of their similarity. This tuned temporal smoothing likely promotes the stability of memory in the face of noise and occlusion. Serial dependence accumulates over several seconds in memory and deteriorates with increased separation between trials. While this phenomenon has been extensively characterized in behavior, its neural mechanism is unknown. In the present study, we investigate the circuit-level origins of serial dependence in a biophysical model of cortex. We explore two distinct kinds of mechanisms: stable persistent activity during the memory delay period and dynamic "activity-silent" synaptic plasticity. We find

SUBMITTER: Bliss DP 

PROVIDER: S-EPMC5731753 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature