Diagnostic markers for the detection of ovarian cancer in BRCA1 mutation carriers.

ABSTRACT:

Background

Screening for ovarian cancer (OC) in women at high risk consists of a combination of carbohydrate antigen 125 (CA125) and transvaginal ultrasound, despite their low sensitivity and specificity. This could be improved by the combination of several biomarkers, which has been shown in average risk patients but has not been investigated until now in female BRCA mutation carriers.

Methods

Using a multiplex, bead-based, immunoassay system, we analyzed the concentrations of leptin, prolactin, osteopontin, insulin-like growth factor II, macrophage inhibitory factor, CA125 and human epididymis antigen 4 in 26 healthy wild type women, 26 healthy BRCA1 mutation carriers, 28 wildtype OC patients and 26 OC patients with BRCA1 mutation.

Results

Using the ROC analysis, we

SUBMITTER: Gschwantler-Kaulich D 

PROVIDER: S-EPMC5731824 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature