Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study.

ABSTRACT: Urokinase plasminogen activator receptor (PLAUR) has been implicated in a variety of physiological and pathological conditions. The multi-functionality of PLAUR is due to its capacity to interact with many co-receptors to regulate extracellular proteolysis and intracellular signaling. Recent reports are identifying novel functions of PLAUR which were not evident in the past; however, the molecular mechanisms of PLAUR signaling are not completely understood. Here, we have compared the transcriptomes of silencing control (sicon) and PLAUR silenced (PLAURsi) MDA-MB-231 breast cancer cells on treatment with radiation. We isolated RNA from the cells, synthesized cDNA and measured the gene expression changes by microarray. We identified 24 downregulated and 53 upregulated genes, which were signi

SUBMITTER: Narayanaswamy PB 

PROVIDER: S-EPMC5731897 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature