Treatment outcomes regarding the addition of targeted agents in the therapeutic portfolio for stage II-III rectal cancer undergoing neoadjuvant chemoradiation.

ABSTRACT:

Background

To evaluate the impact of targeted agents in stage II-III rectal cancer undergoing neoadjuvant concurrent chemoradiation therapy (CCRT).

Method

A retrospective study was performed in 124 consecutive patients with clinically T₃N_0-2M₀-staged rectal cancer incorporating targeted agents in CCRT.

Results

Pathologic complete response was detected in 34.2% (n=26) of bevacizumab+FOLFOX-treated patients (n=76), which was significantly higher (p=0.019, post-hoc statistical power =35.87%) than that (n=10, 20.8%) of the cetuximab+FOLFOX-treated patients (n=48). Patients receiving cetuximab+FOLFOX therapy tended to develop severe liver toxicity (91.7%, n=44 versus 17.1%, n=13, p<0.0001), as evaluated by morphologic grading of hepatic ste

SUBMITTER: Liang JT 

PROVIDER: S-EPMC5731917 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature