Genetic polymorphisms in the ALDH2 gene and the risk of ischemic stroke in a Chinese han population.

ABSTRACT:

Background

Previous studies have shown that aldehyde dehydrogenase 2 (ALDH2) plays a role in ischemic stroke progression. In recent years, the activation of the ALDH2 pathway have been reported serving as a useful index in the identification of stroke-prone participants, and the ALDH2 pathway may be a potential target for the therapeutic intervention in ischemic stroke.

Materials and methods

We evaluated six tagging single-nucleotide polymorphisms (SNPs) of the ALDH2 gene in a case-control study from Hainan of China (488 cases, 503 controls). We used SPSS version 17.0 statistical software, Excel software and other analysis software to explore associations between SNPs and the risk of ischemic stroke various genetic models (additive, dominant, and

SUBMITTER: Sun S 

PROVIDER: S-EPMC5731925 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature