Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells from non-small cell lung cancer patients.

ABSTRACT: Binding of programmed death-1 (PD-1) with its ligands (PD-L1/2) transmits a co-inhibitory signal in activated T-cells that promotes T-cell exhaustion, leading to tumor immune evasion. The efficacy of antibodies targeting PD-1 and PD-L1 has led to a paradigm shift in lung cancer treatment but the prognostic and predictive value of tumor PD-L1 expression remains controversial. Evaluating PD-1, PD-L1/2 expression in peripheral blood cells may serve as a potential biomarker for prognosis and response to therapy. In this prospective observational study, plasma cytokine levels and PD-1, PD-L1 and PD-L2 expression was evaluated in circulating CD3⁺, CD3⁺CD4⁺ and CD3⁺CD8⁺ cells from 70 treatment-naïve patients with advanced NSCLC (Stage IIIB an

SUBMITTER: Arrieta O 

PROVIDER: S-EPMC5731930 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature