Association between CD40 rs1883832 and immune-related diseases susceptibility: A meta-analysis.

ABSTRACT:

Background/objective

It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case-control studies to summarize and clarify this association.

Methods/main results

A systematic search of studies on the association between CD40 rs1883832 and immune-related diseases susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size. 40 articles were included in our meta-analysis.

Conclusions

CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the s

SUBMITTER: Qin J 

PROVIDER: S-EPMC5731949 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature