NQO1 C609T polymorphism and lung cancer susceptibility: Evidence from a comprehensive meta-analysis.

ABSTRACT: A variety of case-control studies have been performed to assess the correlation between NQO1 C609T polymorphism and the risk of lung cancer, but an explicit consensus has not been reached. We conducted this updated meta-analysis to identify the function of NQO1 C609T polymorphism in lung cancer risk. All relevant literature was retrieved from the PubMed, EMBASE, CNKI, and WanFang databases before April 2017. A total of 37 studies (29 articles) with 8493 cases and 10,999 controls were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of relations. We found that the NQO1 C609T polymorphism did not correlate with the risk of lung cancer in the overall analysis. In addition, no statistical significance was observed in the analy

SUBMITTER: Huang J 

PROVIDER: S-EPMC5731955 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature