Meta-analysis identifies candidate key genes in endometrium as predictive biomarkers for clinical pregnancy in IVF.

ABSTRACT: Genetic factors in endometrium are likely to be involved in the embryo implantation failure (IF), one of the major limiting factors in the success of in vitro fertilization (IVF). In this study, we aimed to identify critical genes from the transcriptional profile for the establishment of the endometrial receptivity which supporting the normal pregnancy. Three GEO datasets, including 12 samples of IF and 12 samples of controls, were used for the meta-analysis. We identified 182 different expression genes (DEGs) by comparing IF with controls and present here the successful clustering according to sample type, not by the origin. The gene ontology (GO) enriched analysis demonstrated the significant downregulation in activation and regulation of inflammatory and immune response in IF pat

SUBMITTER: Li J 

PROVIDER: S-EPMC5731968 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature