Alterations in oral bacterial communities are associated with risk factors for oral and oropharyngeal cancer.

ABSTRACT: Oral squamous cell carcinomas are a major cause of morbidity and mortality, and tobacco usage, alcohol consumption, and poor oral hygiene are established risk factors. To date, no large-scale case-control studies have considered the effects of these risk factors on the composition of the oral microbiome, nor microbial community associations with oral cancer. We compared the composition, diversity, and function of the oral microbiomes of 121 oral cancer patients to 242 age- and gender-matched controls using a metagenomic multivariate analysis pipeline. Significant shifts in composition and function of the oral microbiome were observed with poor oral hygiene, tobacco smoking, and oral cancer. Specifically, we observed dramatically altered community composition and function after tooth loss,

SUBMITTER: Bornigen D 

PROVIDER: S-EPMC5732161 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature