Ag-doping regulates the cytotoxicity of TiO₂ nanoparticles via oxidative stress in human cancer cells.

ABSTRACT: We investigated the anticancer potential of Ag-doped (0.5-5%) anatase TiO₂ NPs. Characterization study showed that dopant Ag was well-distributed on the surface of host TiO₂ NPs. Size (15 nm to 9 nm) and band gap energy (3.32 eV to 3.15 eV) of TiO₂ NPs were decreases with increasing the concentration of Ag dopant. Biological studies demonstrated that Ag-doped TiO₂ NP-induced cytotoxicity and apoptosis in human liver cancer (HepG2) cells. The toxic intensity of TiO₂ NPs was increases with increasing the amount of Ag-doping. The Ag-doped TiO₂ NPs further found to provoke reactive oxygen species (ROS) generation and antioxidants depletion. Toxicity induced by Ag-doped TiO₂ NPs in HepG2 cells was efficiently abrogated

SUBMITTER: Ahamed M 

PROVIDER: S-EPMC5732217 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature