Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects.

ABSTRACT: Each year, 33% of US citizens suffer from a musculoskeletal condition that requires medical intervention, with direct medical costs approaching $1 trillion USD per year. Despite the ubiquity of skeletal dysfunction, there are currently limited safe and efficacious bone growth factors in clinical use. Notch is a cell-cell communication pathway that regulates self-renewal and differentiation within the mesenchymal/osteoblast lineage. The principal Notch ligand in bone, Jagged-1, is a potent osteoinductive protein that positively regulates post-traumatic bone healing in animals. This report describes the temporal regulation of Notch during intramembranous bone formation using marrow ablation as a model system and demonstrates decreased bone formation following disruption of Jagged-1 in mesenc

SUBMITTER: Youngstrom DW 

PROVIDER: S-EPMC5732299 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature