Posterior atrophy predicts time to dementia in patients with amyloid-positive mild cognitive impairment.

ABSTRACT:

Background

In patients with amyloid-positive mild cognitive impairment (MCI), neurodegenerative biomarkers such as medial temporal lobe atrophy (MTA) are useful to predict disease progression to dementia. Although posterior atrophy (PA) is a well-known neurodegenerative biomarker of Alzheimer's disease, little is known about PA as a predictor in patients with amyloid-positive MCI.

Methods

We included 258 patients with amyloid-positive MCI with at least one follow-up visit, and who had low cerebrospinal fluid (CSF) β-amyloid_1-42 concentration. Data were obtained from the Alzheimer's Disease Neuroimaging Initiative study. We assessed PA and MTA on magnetic resonance imaging (MRI) using visual rating scales and retrospectively determined progression to dementia durin

SUBMITTER: Pyun JM 

PROVIDER: S-EPMC5732486 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature