Characterization of plasma proteins in children of different Mycobacterium tuberculosis infection status using label-free quantitative proteomics.

ABSTRACT: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is an infectious disease found worldwide. Children infected with MTB are more likely to progress to active TB (ATB); however, the molecular mechanism behind this process has long been a mystery. We employed the label-free quantitative proteomic technology to identify and characterize differences in plasma proteins between ATB and latent TB infection (LTBI) in children. To detect differences that are indicative of MTB infection, we first selected proteins whose expressions were markedly different between the ATB and LTBI groups and the control groups (inflammatory disease control (IDC) and healthy control (HC) groups). A total of 521 proteins differed (> 1.5-fold or < 0.6-fold) in the LTBI group, and 318 proteins in the A

SUBMITTER: Li J 

PROVIDER: S-EPMC5732728 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature