Prioritizing chronic obstructive pulmonary disease (COPD) candidate genes in COPD-related networks.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a multi-factor disease, which could be caused by many factors, including disturbances of metabolism and protein-protein interactions (PPIs). In this paper, a weighted COPD-related metabolic network and a weighted COPD-related PPI network were constructed base on COPD disease genes and functional information. Candidate genes in these weighted COPD-related networks were prioritized by making use of a gene prioritization method, respectively. Literature review and functional enrichment analysis of the top 100 genes in these two networks suggested the correlation of COPD and these genes. The performance of our gene prioritization method was superior to that of ToppGene and ToppNet for genes from the COPD-related metabolic network or the COPD-rela

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5732734 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature