Comparison of immune microenvironments between primary tumors and brain metastases in patients with breast cancer.

ABSTRACT:

Background

Immune checkpoint inhibitors are reported to be effective in patients with brain metastases. However, detailed characteristics of the brain metastasis immune microenvironment remain unexplored.

Results

The median tumor-infiltrating lymphocyte (TIL) category in brain metastases was 5% (1-70%). In 46 pair-matched samples, the percentages of TILs were significantly higher in primary breast tumors than in brain metastases (paired t-test, P < 0.01). The numbers of CD4/CD8/Foxp3-positive cells were significantly higher in primary breast tumors than in brain metastases (paired t-test, P < 0.05 for all antibodies). In patients with triple-negative breast cancer specifically, low TIL numbers were associated with significantly shorter overall survival c

SUBMITTER: Ogiya R 

PROVIDER: S-EPMC5732758 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature