Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model.

ABSTRACT: Folate impacts the genome and epigenome by feeding into one-carbon metabolism to produce critical metabolites, deoxythymidine monophosphate and s-adenosylmethionine. The impact of folate exposure and intervention timing on cancer progression remains controversial. Due to polyamine metabolism's extraordinary biosynthetic flux in prostate cancer (CaP) we demonstrated androgen stimulated CaP is susceptible to dietary folate deficiency. We hypothesized dietary folate levels may also affect castration recurrent CaP. We used the CWR22 human xenograft model which recurs following androgen withdrawal. Engrafted mice were fed a folate depleted or supplemented diet beginning at androgen withdrawal, or prior to xenograft implantation. Both folate depletion and supplementation at the time of withdrawa

SUBMITTER: Affronti HC 

PROVIDER: S-EPMC5732764 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature