Elevated serum urate is a potential factor in reduction of total bilirubin: a Mendelian randomization study.

ABSTRACT:

Aim

A Mendelian randomization study (MRS) can be linked to a "natural" randomized controlled trial in order to avoid potential bias of observational epidemiology. We aimed to study the possible association between serum urate (SU) and total bilirubin (TBIL) using MRS.

Materials and methods

An observational epidemiological study using ordinary least squares (OLS) regression and MRS using two-stage least square (TLS) regression was conducted to assess the effect of SU on TBIL. The comparison between the OLS regression and the TLS regression was analyzed by the Durbin-Hausman test. If the p value is significant, it suggests that the OLS regression cannot evaluate the relationship between exposure and outcome, and the TLS regression is precise; while if the p value

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5732772 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature