Microtubins: a novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation.

ABSTRACT: Microtubule targeting drugs like taxanes, vinca alkaloids, and epothilones are widely-used and effective chemotherapeutic agents that target the dynamic instability of microtubules and inhibit spindle functioning. However, these drugs have limitations associated with their production, solubility, efficacy and unwanted toxicities, thus driving the need to identify novel antimitotic drugs that can be used as anticancer agents. We have discovered and characterized the Microtubins (Microtubule inhibitors), a novel class of small synthetic compounds, which target tubulin to inhibit microtubule polymerization, arrest cancer cells predominantly in mitosis, activate the spindle assembly checkpoint and trigger an apoptotic cell death. Importantly, the Microtubins do not compete for the known vinca

SUBMITTER: Senese S 

PROVIDER: S-EPMC5732783 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature