Thiamine in septic shock patients with alcohol use disorders: An observational pilot study.

ABSTRACT:

Purpose

Alcohol-use disorders (AUDs) have been associated with increased sepsis-related mortality. As patients with AUDs are often thiamine deficient, we investigated practice patterns relating to thiamine administration in patients with AUDs presenting with septic shock and explored the association between receipt of thiamine and mortality.

Materials

We performed a retrospective cohort study of patients presenting with septic shock between 2008 and 2014 at a single tertiary care center. We identified patients with an AUD diagnosis, orders for microbial cultures and use of antibiotics, vasopressor dependency, and lactate levels≥4mmol/L. We excluded those who received thiamine later than 48h of sepsis onset.

Results

We included 53 patients. Thirty-four (64%) patients r

SUBMITTER: Holmberg MJ 

PROVIDER: S-EPMC5732860 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature