Metabolic phenotyping using kinetic measurements in young and older healthy adults.

ABSTRACT:

Background

The aging process is often associated with the presence of sarcopenia. Although changes in the plasma concentration of several amino acids have been observed in older adults, it remains unclear whether these changes are related to disturbances in whole body production and/or interconversions.

Methods

We studied 10 healthy young (~22.7y) and 17 older adults (~64.8y) by administering a mixture of stable amino acid tracers in a pulse and in a primed constant infusion. We calculated whole body production (WBP) and metabolite to metabolite interconversions. In addition, we measured body composition, muscle function, and provided questionnaires to assess daily dietary intake, physical activity, mood (anxiety, depression) and markers of cognitive function. Plasma enrichm

SUBMITTER: Deutz NEP 

PROVIDER: S-EPMC5732887 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature