Immunization with Live Attenuated Leishmania donovani Centrin^-/- Parasites Is Efficacious in Asymptomatic Infection.

ABSTRACT: Currently, there is no vaccine against visceral leishmaniasis (VL). Toward developing an effective vaccine, we have reported extensively on the immunogenicity of live attenuated LdCentrin^-/- mutants in naive animal models. In VL endemic areas, asymptomatic carriers outnumber symptomatic cases of VL and are considered to be a reservoir of infection. Vaccination of asymptomatic cases represents a viable strategy to eliminate VL. Immunological correlates of protection thus derived might have limited applicability in conditions where the immunized host has prior exposure to virulent infection. To examine whether LdCen^-/- parasites can induce protective immunity in experimental hosts that have low-level parasitemia from a previous exposure mimicking an asympt

SUBMITTER: Ismail N 

PROVIDER: S-EPMC5732910 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature