Developmental Changes in Sensory-Evoked Optical Intrinsic Signals in the Rat Barrel Cortex.

ABSTRACT: Optical Intrinsic Signal imaging (OISi) is a powerful technique for optical brain studies. OIS mainly reflects the hemodynamic response (HR) and metabolism, but it may also involve changes in tissue light scattering (LS) caused by transient cellular swelling in the active tissue. Here, we explored the developmental features of sensory-evoked OIS in the rat barrel cortex during the first 3 months after birth. Multispectral OISi revealed that two temporally distinct components contribute to the neonatal OIS: an early phase of LS followed by a late phase of HR. The contribution of LS to the early response was also evidenced by an increase in light transmission through the active barrel. The early OIS phase correlated in time and amplitude with the sensory-evoked electrophysiological response.

SUBMITTER: Sintsov M 

PROVIDER: S-EPMC5733043 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature