Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis.

ABSTRACT:

Background

The vitamin D receptor (VDR) gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D. Polymorphism in VDR causes alterations in the functioning of vitamin D, leading to type 1 diabetes (T1D) predisposition. The aim of the present study was to determine VDR gene polymorphism in association with T1D in Pakistanis.

Methods

The association was evaluated by selecting rs2228570 (FokΙ), rs7975232 (ApaΙ), and rs731236 (TaqΙ) polymorphic sites in 102 patients and 100 controls. Genotypes were identified by DNA sequencing and PCR-RFLP.

Results

The allelic and genotypic frequencies of FokΙ and ApaI were significantly associated with T1D (p < 0.001)

SUBMITTER: Mukhtar M 

PROVIDER: S-EPMC5733195 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature