CD4 count and tuberculosis risk in HIV-positive adults not on ART: a systematic review and meta-analysis.

ABSTRACT:

Background

CD4 cell count in adults with human immunodeficiency virus (HIV) infection (PLHIV) not receiving antiretroviral therapy (ART) influences tuberculosis (TB) risk. Despite widespread use in models informing resource allocation, this relationship has not been systematically reviewed.

Methods

We systematically searched MEDLINE, Aidsinfo, Cochrane review database and Google Scholar for reports in English describing TB incidence stratified by updated CD4 cell count in cohorts of HIV-positive adults (age ≥15 years) not on ART (PROSPERO protocol no: CRD42016048888). Among inclusion criteria were: reporting precision for TB incidence, repeated CD4 measurements, and TB incidence reported for those not on ART or monotherapy. Study quality was assessed via the Newcastle-Ottawa

SUBMITTER: Ellis PK 

PROVIDER: S-EPMC5733368 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature