Savings memory is accompanied by transcriptional changes that persist beyond the decay of recall.

ABSTRACT: Most long-term memories are forgotten. What happens, then, to the changes in neuronal gene expression that were initially required to encode and maintain the memory? Here we show that the decay of recall for long-term sensitization memory in Aplysia is accompanied both by a form of savings memory (easier relearning) and by persistent transcriptional regulation. A behavioral experiment (N = 14) shows that sensitization training produces a robust long-term sensitization memory, but that recall fades completely within 1 wk. This apparent forgetting, though, is belied by persistent savings memory, as we found that a weak reminder protocol reinstates a long-term sensitization memory only on the previously trained side of the body. Using microarray (N = 8 biological replicat

SUBMITTER: Perez L 

PROVIDER: S-EPMC5733468 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature