Stress leads to aberrant hippocampal involvement when processing schema-related information.

ABSTRACT: Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus, however, is crucial for encoding schema-unrelated information but not for schema-related information. A recent study indicated that stress mediators may affect schema-related memory, but the underlying neural mechanisms are currently unknown. Here, we thus tested the impact of acute stress on neural processing of schema-related information. We exposed healthy participants to a stress or control manipulation before they processed, in the MRI scanner, words related or unrelated to a preexisting s

SUBMITTER: Vogel S 

PROVIDER: S-EPMC5733469 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature