RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.

ABSTRACT: Lung cancer is the leading cause of cancer deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung cancer in women; however, the underlying mechanisms remain unclear. Here we report that the receptor activator of nuclear factor-kB (RANK), the key regulator of osteoclastogenesis, is frequently expressed in primary lung tumors, an active RANK pathway correlates with decreased survival, and pharmacologic RANK inhibition reduces tumor growth in patient-derived lung cancer xenografts. Clonal genetic inactivation of KRas^G12D in mouse lung epithelial cells markedly impairs the progression of KRas^G12D -driven lung cancer, resulting in a significant survival advantage. Mechanistically, RANK rewires energy homeostasis

SUBMITTER: Rao S 

PROVIDER: S-EPMC5733500 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature