Innate immune recognition of double-stranded RNA triggers increased expression of NKG2D ligands after virus infection.

ABSTRACT: Self/non-self-discrimination by the innate immune system relies on germline-encoded, non-rearranging receptors expressed by innate immune cells recognizing conserved pathogen-associated molecular patterns. The natural killer group 2D (NKG2D) receptor is a potent immune-activating receptor that binds human genome-encoded ligands, whose expression is negligible in normal tissues, but increased in stress and disease conditions for reasons that are incompletely understood. Here it is not clear how the immune system reconciles receptor binding of self-proteins with self/non-self-discrimination to avoid autoreactivity. We now report that increased expression of NKG2D ligands after virus infection depends on interferon response factors activated by the detection of viral double-stranded RNA by pa

SUBMITTER: Esteso G 

PROVIDER: S-EPMC5733586 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature