The TRPC1 Ca²⁺-permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes.

ABSTRACT: The transient receptor potential canonical channel-1 (TRPC1) is a Ca²⁺-permeable channel found in key metabolic organs and tissues, including the hypothalamus, adipose tissue, and skeletal muscle. Loss of TRPC1 may alter the regulation of cellular energy metabolism resulting in insulin resistance thereby leading to diabetes. Exercise reduces insulin resistance, but it is not known whether TRPC1 is involved in exercise-induced insulin sensitivity. The role of TRPC1 in adiposity and obesity-associated metabolic diseases has not yet been determined. Our results show that TRPC1 functions as a major Ca²⁺ entry channel in adipocytes. We have also shown that fat mass and fasting glucose concentrations were lower in TRPC1 KO mice that were fed a high-fat (HF) (45% fat) diet a

SUBMITTER: Krout D 

PROVIDER: S-EPMC5733613 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature