Effect of Thrombotic Microangiopathy on Clinical Outcomes in Indian Patients With Lupus Nephritis.

ABSTRACT:

Introduction

In addition to glomerular lesion, renal vascular lesion is also an important prognostic marker of lupus nephritis (LN). Among patients with various vascular changes, individuals with thrombotic microangiopathy (TMA) present with severe clinical manifestations and have a high mortality. The aim of the present study was to assess the spectrum and impact of TMA on the outcomes of LN. In a prospective observational study of 2.5 years' duration, clinical and renal histopathological data regarding biopsy-proven LN were noted, and evaluation for antiphospholipid syndrome (APS) as a cause of TMA in LN was also carried out.

Methods

Study subjects were followed up actively for 6 months, and various outcomes were noted. Cases were divided into 2 groups as LN with TMA and L

SUBMITTER: Pattanashetti N 

PROVIDER: S-EPMC5733673 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature