Coupling between myosin head conformation and the thick filament backbone structure.

ABSTRACT: The recent high-resolution structure of the thick filament from Lethocerus asynchronous flight muscle shows aspects of thick filament structure never before revealed that may shed some light on how striated muscles function. The phenomenon of stretch activation underlies the function of asynchronous flight muscle. It is most highly developed in flight muscle, but is also observed in other striated muscles such as cardiac muscle. Although stretch activation is likely to be complex, involving more than a single structural aspect of striated muscle, the thick filament itself, would be a prime site for regulatory function because it must bear all of the tension produced by both its associated myosin motors and any externally applied force. Here we show the first structural evidence that the ar

SUBMITTER: Hu Z 

PROVIDER: S-EPMC5733691 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature