Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.

ABSTRACT: PURPOSE OF REVIEW:The purpose of this review is to describe recent findings in the context of previous work regarding dysregulated myelopoiesis and hematopoietic function following an acute physiologic insult, focusing on the expansion and persistence of myeloid-deriver suppressor cells, the deterioration of lymphocyte number and function, and the inadequacy of stress erythropoiesis. RECENT FINDINGS:Persistent myeloid-derived suppressor cell (MDSC) expansion among critically ill septic patients is associated with T-cell suppression, vulnerability to nosocomial infection, chronic critical illness, and poor long-term functional status. Multiple approaches targeting MDSC expansion and suppressor cell activity may serve as a primary or adjunctive therapeutic intervention. Traumatic injury and

SUBMITTER: Loftus TJ 

PROVIDER: S-EPMC5733709 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature