Thrombocytopenia Is Associated With Multi-organ System Failure in Patients With Acute Liver Failure.

ABSTRACT:

Background & aims

Acute liver failure (ALF) is a syndrome characterized by an intense systemic inflammatory response (SIRS) and multi-organ system failure (MOSF). Platelet-derived microparticles increase in proportion to the severity of the SIRS and MOSF, and are associated with poor outcome. We investigated whether patients with ALF develop thrombocytopenia in proportion to the SIRS, MOSF, and poor outcome.

Methods

In a retrospective study, we collected data on the post-admission platelet counts of 1598 patients included in the ALF Study Group Registry from 1998 through October 2012. We investigated correlations between platelet counts and clinical features of ALF, laboratory test results, and outcomes. Of the patients studied, 752 (47%) survived without liver transplantati

SUBMITTER: Stravitz RT 

PROVIDER: S-EPMC5733710 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature