Altered Protein Composition of Subcutaneous Adipose Tissue in Chronic Kidney Disease.

ABSTRACT:

Introduction

Loss of renal function is associated with high mortality from cardiovascular disease (CVD). Patients with chronic kidney disease (CKD) have altered circulating adipokine and nonesterified fatty acid concentrations and insulin resistance, which are features of disturbed adipose tissue metabolism. Because dysfunctional adipose tissue contributes to the development of CVD, we hypothesize that adipose tissue dysfunctionality in patients with CKD could explain, at least in part, their high rates of CVD. Therefore we characterized adipose tissue from patients with CKD, in comparison to healthy controls, to search for signs of dysfunctionality.

Methods

Biopsy samples of subcutaneous adipose tissue from 16 CKD patients and 11 healthy controls were analyzed for inflammat

SUBMITTER: Gertow J 

PROVIDER: S-EPMC5733748 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature