Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy.

ABSTRACT:

Introduction

IgA nephropathy is a chronic renal disease characterized by mesangial immunodeposits that contain autoantigen, which is aberrantly glycosylated IgA1 with some hinge-region O-glycans deficient in galactose. Macroscopic hematuria during an upper respiratory tract infection is common among patients with IgA nephropathy, which suggests a connection between inflammation and disease activity. Interleukin-6 (IL-6) is an inflammatory cytokine involved in IgA immune response. We previously showed that IL-6 selectively increases production of galactose-deficient IgA1 in IgA1-secreting cells from patients with IgA nephropathy.

Methods

We characterized IL-6 signaling pathways involved in the overproduction of galactose-deficient IgA1. To understand molecular mechanis

SUBMITTER: Yamada K 

PROVIDER: S-EPMC5733772 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature