The role of acuity of illness at presentation in early mortality in black children with acute myeloid leukemia.

ABSTRACT: Black patients with acute myeloid leukemia (AML) experience higher mortality than White patients. We compared induction mortality, acuity of illness prior to chemotherapy, and insurance type between Black and White patients to assess whether acuity of presentation mediates the disparity. Within a retrospective cohort of 1,122 children with AML treated with two courses of standard induction chemotherapy between 2004 and 2014 in the Pediatric Health Information System (PHIS) database, the association between race (Black versus White) and inpatient mortality during induction was examined. Intensive Care Unit (ICU)-level resource utilization during the first 72 hours following admission for initial AML chemotherapy was evaluated as a potential mediator. The total effect of race on mortality du

SUBMITTER: Winestone LE 

PROVIDER: S-EPMC5733783 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature