Impact of Regular or Extended Hemodialysis and Hemodialfiltration on Plasma Oxalate Concentrations in Patients With End-Stage Renal Disease.

ABSTRACT:

Introduction

Calcium oxalate supersaturation is regularly exceeded in the plasma of patients with end-stage renal disease (ESRD). Previous reports have indicated that hemodialfiltration (HDF) lowers elevated plasma oxalate (P_Ox) concentrations more effectively compared with hemodialysis (HD). We reevaluate the therapeutic strategy for optimized P_Ox reduction with advanced dialysis equipment and provide data on the effect of extended treatment time on dialytic oxalate kinetics.

Methods

Fourteen patients with ESRD who underwent HDF 3 times a week for 4 to 4.5 hours (regular HDF; n = 8) or 7 to 7.5 hours (extended HDF; n = 6) were changed to HD for 2 weeks and then back to HDF for another 2 weeks. P_Ox was measured at baseline, pre-, mid-, and po

SUBMITTER: Ermer T 

PROVIDER: S-EPMC5733827 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature