Modeling HIV-HCV coinfection epidemiology in the direct-acting antiviral era: the road to elimination.

ABSTRACT:

Background

HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model.

Methods

The model was based on epidemiological data from the French Dat'AIDS cohort. Eight risk groups were considered, including high-risk (HR) and low-risk (LR) men who have sex with men (MSM) and male/female heterosexuals, intra-venous drug users, or patients from other risk groups. The model was calibrated on prevalence and incidence data observed in

SUBMITTER: Virlogeux V 

PROVIDER: S-EPMC5733872 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature