Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH.

ABSTRACT:

Introduction

Urine pH is critical for net acid and solute excretion, but the genetic factors that contribute to its regulation are incompletely understood.

Methods

We tested the association of single nucleotide polymorphisms (SNPs) from 16 genes related to ammonia (NH₃) metabolism (15 biological candidates selected a priori, 1 selected from a previous genome-wide association study analysis) to that of 24-hour urine pH in 2493 individuals of European descent across 2 different cohorts using linear regression, adjusting for age, sex, and body mass index.

Results

Of 2871 total SNPs in these genes, 13 SNPs in ATP6V0A4 (a4 subunit of hydrogen- adenosine triphosphatase), SLC9A3 (sodium/hydrogen exchanger, isoform 3), and RHCG (Rhesus C

SUBMITTER: Canales BK 

PROVIDER: S-EPMC5733879 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature