Biological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment.

ABSTRACT: In mild cognitive impairment (MCI), small benefits from cognitive training were observed for memory functions but there appears to be great variability in the response to treatment. Our study aimed to improve the characterization and selection of those participants who will benefit from cognitive intervention. We evaluated the predictive value of disease-specific biological factors for the outcome after cognitive training in MCI (n = 25) and also considered motivation of the participants. We compared the results of the cognitive intervention group with two independent control groups of MCI patients (local memory clinic, n = 20; ADNI cohort, n = 302). The primary outcome measure was episodic memory as measured by verbal delayed recall of a 10-word list. Episodic memory remained stable after

SUBMITTER: Peter J 

PROVIDER: S-EPMC5734129 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature