%MinMax: A versatile tool for calculating and comparing synonymous codon usage and its impact on protein folding.

ABSTRACT: Most amino acids can be encoded by more than one synonymous codon, but these are rarely used with equal frequency. In many coding sequences the usage patterns of rare versus common synonymous codons is nonrandom and under selection. Moreover, synonymous substitutions that alter these patterns can have a substantial impact on the folding efficiency of the encoded protein. This has ignited broad interest in exploring synonymous codon usage patterns. For many protein chemists, biophysicists and structural biologists, the primary motivation for codon analysis is identifying and preserving usage patterns most likely to impact high-yield production of functional proteins. Here we describe the core functions and new features of %MinMax, a codon usage calculator freely available as a web-based por

SUBMITTER: Rodriguez A 

PROVIDER: S-EPMC5734269 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature