Factors associated with non-persistence to oral and inhaled antiviral therapies for seasonal influenza: a secondary analysis of a double-blind, multicentre, randomised clinical trial.

ABSTRACT:

Objectives

We aimed to evaluate and compare non-adherence to oral and inhaled antiviral therapies prescribed of a randomised clinical trial in outpatients with influenza A infection.

Design

A parallel, three-arm, double-blinded trial randomly allocated antiviral therapies twice daily for 5 days: (1) oral oseltamivir plus inhaled zanamivir (arm OZ); (2) oseltamivir plus inhaled placebo (arm Opz); or (3) oral placebo plus inhaled zanamivir (arm poZ). Analysis of non-adherence was a secondary objective of the trial.

Settings

Outpatients were enrolled by 145 general practitioners throughout France during the 2008-2009 seasonal influenza epidemics.

Participants

A total of 541 adults presenting with influenza-like illness for less than 36 hours.

Primary outcomes</

SUBMITTER: Flicoteaux R 

PROVIDER: S-EPMC5734282 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature