Timing of two versus three doses of quadrivalent HPV vaccine and associated effectiveness against condyloma in Sweden: a nationwide cohort study.

ABSTRACT:

Objective

To assess incidence of condyloma after two doses of quadrivalent human papillomavirus (qHPV) vaccine, by time since first vaccine dose, in girls and women initiating vaccination before age 20 years.

Design

Register-based nationwide open cohort study.

Setting

Sweden.

Participants

Girls and women initiating qHPV vaccination before age 20 years between 2006 and 2012. The study cohort included 264 498 girls, of whom 72 042 had received two doses of qHPV vaccine and 185 456 had received all three doses.

Main outcome measure

Incidence rate ratios (IRRs) of condyloma estimated by time between first and second doses of qHPV in months (m) and age at vaccination, adjusted for attained age.

Results

For girls first vaccinated with two doses before t

SUBMITTER: Lamb F 

PROVIDER: S-EPMC5734289 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature