Effect of corticosteroid administration on neurologically deceased organ donors and transplant recipients: a systematic review and meta-analysis.

ABSTRACT:

Objectives

This review investigates the impact of corticosteroids on donation rates and transplant outcomes in light of findings from randomised controlled trials (RCTs) and to highlight the sources of uncertainty in this unresolved donor management issue.

Data sources

We searched electronic databases, trial registries and conference proceedings for RCTs evaluating corticosteroid therapy in neurologically deceased donors.

Study selection and data extraction

Independent reviewers assessed eligibility, evaluated risk of bias and abstracted data, including donor haemodynamic data, number of organs recovered and transplant outcomes. Where possible, we pooled results. For each outcome, we assessed the overall quality of evidence using The Grading of Recommendations Assessm

SUBMITTER: D'Aragon F 

PROVIDER: S-EPMC5734295 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature