Bioinformatic Analysis of Circadian Expression of Oncogenes and Tumor Suppressor Genes.

ABSTRACT:

Background

Circadian rhythms are physiological and behavioral cycles with a period of approximately 24 hours that control various functions including gene expression. Circadian disruption is associated with a variety of diseases, especially cancer. Although some of the oncogenes and tumor suppressor genes (TSGs) are known as clock-controlled genes (CCGs), the analysis and annotation of circadian expression of most human oncogenes and TSGs are still lacking. This study aims to investigate the circadian expression of a list of human oncogenes and TSGs.

Methods

A bioinformatic analysis was conducted on a gene library comprising 120 genes to investigate the circadian expression of human oncogenes and TSGs. To achieve this purpose, the genotranscriptomic data were retrieved from

SUBMITTER: Salavaty A 

PROVIDER: S-EPMC5734456 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature