Iron Deficiency Affects Seizure Susceptibility in a Time- and Sex-Specific Manner.

ABSTRACT: Iron deficiency (ID) affects more than three billion people worldwide making it the most common micronutrient deficiency. ID is most prevalent during gestation and early life, which is of particular concern since its impact on the developing central nervous system is associated with an increased risk of a wide range of different psychiatric disorders later in life. The cause for this association is not known, but many of these same disorders are also associated with an imbalance between excitation and inhibition (E/I) within the brain. Based on this shared impairment, we asked whether ID could contribute to such an imbalance. Disruptions in the E/I balance can be uncovered by the brain's response to seizure inducing insults. We therefore tested the seizure threshold under different nutriti

SUBMITTER: Rudy M 

PROVIDER: S-EPMC5734468 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature