Neuregulin 3 and its roles in schizophrenia risk and presentation.

ABSTRACT: Neuregulins, a four-member family of epidermal growth factor-like signaling molecules, have been studied for over two decades. They were first implicated in schizophrenia in 2002 with the detection of linkage and association at the NRG1 locus followed after a few years by NRG3. However, the associations with disease have not been very consistently observed. In contrast, association of NGR3 variants with disease presentation, specifically the presence of delusions, has been more consistent. This appears to be mediated by quantitative changes in the alternative splicing of the gene, which has also been consistently observed. Additional diseases and phenotypes, psychiatric or not, have also been connected with NRG3. These results demonstrate two important aspects of behavioral genetics resear

SUBMITTER: Avramopoulos D 

PROVIDER: S-EPMC5735014 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature