The Aging Risk and Atherosclerosis: A Fresh Look at Arterial Homeostasis.

ABSTRACT: A considerable volume of research over the last decade has focused on understanding the fundamental mechanisms for the progression of atherosclerosis-the underlying cause for the vast majority of all cardiovascular (CVD)-related complications. Aging is the dominant risk factor for clinically significant atherosclerotic lesion formation, yet the heightened impact of aging on the disease is not accounted for by changes in traditional risk factors, such as lack of physical activity, smoking, hypertension, hyperlipidemia, or diabetes mellitus. This review will examine the pathological and biochemical processes of atherosclerotic plaque formation and growth, with particular focus on the aging risk vis-a-vis arterial homeostasis. Particular focus will be placed on the impact of a number of impor

SUBMITTER: Head T 

PROVIDER: S-EPMC5735066 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature