The Human Penis Is a Genuine Immunological Effector Site.

ABSTRACT: The human penis is a main portal of entry for numerous pathogens, and vaccines able to control resulting infections locally are highly desirable. However, in contrast to the gastrointestinal or vaginal mucosa, the penile immune system and mechanisms inducing a penile immune response remain elusive. In this descriptive study, using multiparametric flow cytometry and immunohistochemistry, we characterized mucosal immune cells such as B, T, and natural killer (NK) cells from the urethra, fossa, and glans of human adult penile tissues. We show that memory B lymphocytes and CD138⁺ plasma cells are detected in all penile compartments. CD4⁺ and CD8⁺ T lymphocytes reside in the epithelium and lamina propria of the penile regions and have mostly a resting memory phe

SUBMITTER: Sennepin A 

PROVIDER: S-EPMC5735067 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature